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Duodenum Case 9

Prof. Dr. Fatih Aslan

Koc University Hospital

Istanbul, Turkey

Disclaimer:

  • NBI™ and TXI™ Technologies are not intended to replace histopathological sampling as a means of diagnosis​
  • The positions and statements made herein by Prof. Dr. Fatih Aslan are based on Prof. Dr. Fatih Aslan’s experiences, thoughts and opinions. As with any product, results may vary, and the techniques, instruments, and settings can vary from facility to facility. The content hereof should not be considered as a substitute for carefully reading all applicable labeling, including the Instructions for Use. Please thoroughly review the relevant user manual(s) for instructions, risks, warnings, and cautions. Techniques, instruments, and setting can vary from facility to facility. It is the clinician’s decision and responsibility in each clinical situation to decide which products, modes, medications, applications, and settings to use.
  • The EVIS X1™ endoscopy system is not designed for cardiac applications. Other combinations of equipment may cause ventricular fibrillation or seriously affect the cardiac function of the patient. Improper use of endoscopes may result in patient injury, infection, bleeding, and/or perforation. Complete indications, contraindications, warnings, and cautions are available in the Instructions for Use (IFU)​
  • NBI™, RDI™, and TXI™ technologies are 510(k) cleared in the United States. This case study is being furnished to provide examples of NBI™, RDI™, and TXI™ technology use. The GIF-EZ1200 used in this case is not available in the US market at this time, nor is there an established time for its release. The safety and effectiveness of this product and/or the use of these products has not yet been established in the United States market
Procedure information


Scope: GIF-XZ1200, GIF-EZ1500

Case: Duodenal second part tubular adenoma with high grade dysplasia

Organ: Duodenum Second Part

1. WLI

Endoscopic appearance of the adenoma located in the second portion of the duodenum under WLI mode.​

#WLI #A8 structure enhancement #Auto Iris​

2. TXI​™ Technology

Endoscopic appearance of the adenoma located in the second portion of the duodenum under TXI™ technology mode 1.​

#TXI mode 1 #High structure enhancement #Auto Iris​

3. NBI™ technology + magnification​

Appearance of the lesion and surrounding normal mucosa using NBI™ technology and manual optical magnification; irregular vascular patterns observed on the lesion, with regular vascular patterns on the normal mucosa.​

#NBI #A8 structure enhancement #optic magnification​

4. NBI™ technology + magnification​

Appearance of the lesion and surrounding normal mucosa using NBI™ technology and manual optical magnification; irregular vascular patterns observed on the lesion, with regular vascular patterns on the normal mucosa.​

#NBI #A8 structure enhancement #optic magnification​

5. NBI™ technology + magnification​

Appearance of the lesion and surrounding normal mucosa using NBI™ technology and manual zoom magnification; irregular vascular patterns observed on the lesion, with regular vascular patterns on the normal mucosa.​

#NBI #A8 structure enhancement #optic magnification​ ​

6. WLI-Ampulla vater​

WLI mode view of the lesion located in the second portion of the duodenum and the ampulla of Vater.​

#WLI #A8 structure enhancement #Auto Iris

7. WLI​

Endoscopic appearance of the lesion under WLI mode after indigo carmine staining.​

#WLI #A8 structure enhancement #Auto Iris​

8. TXI™ technology

Endoscopic appearance of the lesion under TXI™ technology mode 1 after indigo carmine staining​.

#TXI mode 1 #High structure enhancement #Auto Iris​ ​

9. WLI-ESD​

Intraoperative WLI view during ESD showing the submucosa and muscularis propria.

#WLI #A8 structure enhancement #Auto Iris​

10. TXI™ technology-ESD​

Intraoperative TXI™ technology view during ESD showing the submucosa and muscularis propria; the distinction between submucosa and muscularis propria is clearly visible in TXI™ technology mode.

#TXI mode 1 #High structure enhancement #Auto Iris​

11. WLI-ESD​

Post-ESD view of the resection area under WLI mode.​

#WLI #A8 structure enhancement #Auto Iris​

12. TXI™ technology-ESD​

Post-ESD view of the resection area under TXI™ technology mode; vascular structures and muscularis propria can be visualized more clearly.​ ​

#TXI mode 1 #High structure enhancement #Auto Iris​

13. TXI™ technology-ESD​

Resected specimen pinned on a styrofoam board.

#TXI mode 1 #High structure enhancement #Auto Iris​

Case Video

Pre-procedural assessment of the lesion was performed using the GIF-XZ1200 endoscope. Thanks to its manual optical magnification capability, the entire surface of the lesion was thoroughly examined, aided by the magnifying effect of water immersion. Subsequently, a standard Olympus straight hood was attached to the GIF-EZ1500 endoscope, and the ESD procedure was carried out using the water pressure method with a DualKnife™ device (2.0 mm Knife Length).​ During the procedure, the contrast enhancement provided by TXI™ technology mode was found to be particularly useful for distinguishing the submucosa from the muscularis propria. In addition, the EDOF™ (Extended Depth of Field) technology function of the scope was frequently utilized, enabling close and effective dissection throughout the procedure. These visual advantages are believed to contribute not only to procedural efficiency but also to the prevention of potential adverse events.​ To minimize the risk of delayed complications such as perforation or bleeding, the resection site was securely closed using absorbable barbed sutures.​

Overall Comment

This case highlights the evaluation of an adenoma located in the second portion of the duodenum using various endoscopic imaging modalities, the ability to perform detailed anatomical distinction, and the safe closure of the post-resection defect using a minimally invasive suturing technique following advanced endoscopic resection. Imaging technologies such as TXI™ and NBI™ technology enabled clear visualization of lesion margins and vascular patterns. During the ESD procedure, the enhanced contrast provided by TXI™ technology allowed for clear distinction between the submucosa and muscularis propria layers. After resection, the defect was successfully closed using barbed sutures, thereby reducing the risk of complications. This case demonstrates how novel imaging modes facilitate precise preoperative assessment of duodenal lesions. Furthermore, it underscores how advances in endoscopic technology and instrumentation enable the minimally invasive treatment of premalignant lesions while also allowing for the effective prevention of potential adverse events.

* Specifications, design and accessories are subject to change without any notice or obligation on the part of the manufacturer.

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