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Pancreatobiliary case 3

Jong Ho Moon, MD, PhD, FASGE, FACG, FJGES

Professor of Medicine

Director, Digestive Disease Center

SoonChunHyang University School of Medicine,

Bucheon/Seoul, Korea

Il Sang Shin, MD, PhD

Assistant Professor

Digestive Disease Center

SoonChunHyang University School of Medicine,

Bucheon/Seoul, Korea

Procedure Information


Scope: TJF-Q290V 

Case Findings: Regular follow-up exam for discrimination of ampullary adenoma

Organ: Ampulla of Vater

Patient information: 52-year-old, Female

Medical history: None

1. WLI Observation

A well-defined ampullary lesion with soft consistency

Enhancement : A7
NBI Mode : NA
TXI Mode : NA
RDI Mode : NA
BAI-MC : On

2. NBI Observation

Difficult characterization of ampullary lesion and surrounding mucosa because of bile acid which appear to red color

Enhancement : A7
NBI Mode : 2
TXI Mode : NA
RDI Mode : NA
BAI-MC : On

3. TXI Observation

Accurate identification of the surface structural characteristics including hyperemic microvasculature beneath covering fold with less interference by bile acid

Enhancement : A7
NBI Mode : NA
TXI Mode : 1
RDI Mode : NA
BAI-MC : On

4. TXI Observation

Natural delineation of the surface structure and boundaries with less interference by bile acid

Enhancement : A7
NBI Mode : NA
TXI Mode : 2
RDI Mode : NA
BAI-MC : On

5. RDI Observation

Detailed identification of the lesional margins and surface structure including hyperemic microvasculature beneath covering fold without interference by bile acid

Enhancement : A7
NBI Mode : NA
TXI Mode : NA
RDI Mode : 3
BAI-MC : On

6. NBI observation

Difficult detection and visualization of ampullary lesion and bleeding point after targeted forceps biopsy

Enhancement : A7
NBI Mode : 2
TXI Mode : NA
RDI Mode : NA
BAI-MC : On

7. RDI Treatment

Easier identification of the hemostatic condition and possible bleeding point of ampullary lesion after targeted forceps biopsy

Enhancement : A7
NBI Mode : NA
TXI Mode : NA
RDI Mode : 1
BAI-MC : On

Case Video

This video demonstrates the utility of a new image enhanced endoscopy system in identifying bile acid-rich ampullary lesion. A well-defined ampullary lesion was observed in white-light imaging (WLI), but detailed observation was difficult in narrow-band imaging (NBI) due to the interference from bile acid. TXI modes provided more information of surface structural features including hyperemic microvasculature beneath circular fold with less interference from bile acid. RDI mode 3 provided detailed information of ampullary lesion for targeted forceps biopsy without any interference from bile acid. After forceps biopsy, RDI mode 1 could more easily identify the hemostatic status of the ampulla of Vater, making it easier to determine whether there are bleeding points requiring endoscopic hemostasis compared to NBI. When detailed observation using NBI is difficult due to bile acid, applying TXI and RDI modes can be helpful for accurate evaluation of abnormalities of ampulla of Vater.

Overall Comment

This case suggests that observation using TXI and RDI modes can be useful for the evaluation of suspicious adenomatous lesion of ampulla of Vater. TXI mode can be less disturbed by bile acid than narrow-band imaging and enhanced accurate evaluation of the ampullary lesion including hyperemic microvasculature beneath covering fold by emphasizing color differences of the mucosal surface. RDI mode 3 is not disturbed by bile acids at all, enabling accurate assessment of ampullary lesions and guiding the location for targeted forceps biopsy. Compared to NBI, RDI mode 1 can be more useful because it can effectively identify hemoastatic status and potential bleeding points.

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